Nathan Ihle Selected Research

4- dodecyl- N- (1,3,4- thiadiazol- 2- yl)benzenesulfonamide

3/2010	Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
6/2009	In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

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Nathan Ihle Research Topics

Disease

4	Neoplasms (Cancer) 03/2010 - 01/2004
2	Breast Neoplasms (Breast Cancer) 03/2010 - 01/2004
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2010
1	Weight Loss (Weight Reduction) 03/2010
1	Pancreatic Neoplasms (Pancreatic Cancer) 06/2009
1	Hemolysis 01/2004
1	Colonic Neoplasms (Colon Cancer) 01/2004

Drug/Important Bio-Agent (IBA)

2	4- dodecyl- N- (1,3,4- thiadiazol- 2- yl)benzenesulfonamideIBA 03/2010 - 06/2009
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 03/2010 - 06/2009
1	platelet protein P47 (pleckstrin)IBA 03/2010
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 03/2010
1	Protein Kinases (Protein Kinase)IBA 03/2010
1	Paclitaxel (Taxol)FDA LinkGeneric 03/2010
1	3-Phosphoinositide-Dependent Protein KinasesIBA 09/2008
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 09/2008
1	Phospholipids (Phosphatides)FDA LinkGeneric 09/2008
1	Insulin Receptor Substrate ProteinsIBA 09/2008
1	Phosphatidylinositols (Phosphatidylinositol)IBA 09/2008
1	Dihydrotachysterol (AT 10)IBA 01/2004
1	2-Hydroxypropyl-beta-cyclodextrinIBA 01/2004
1	1- ((1- O- octadecyl- 2- O- methylglycero)phospho)- 3- deoxy- myo- inositolIBA 01/2004
1	WortmanninIBA 01/2004

Therapy/Procedure

1	Intravenous Administration 01/2004